Natto Powder K2

CAS Number: 2124-57-4

Molecular Formula: C46H64O2

Formula Weight: 649.0

Purity: 1000ppm; 2000ppm; 2500ppm; 10000ppm; 13000ppm; 20000ppm

Carrier: Cyclodextrin; Microcrystalline cellulose; Starch

Fermentation: Bacillus subtilis natto

Standards: Complies with USP 40 Monographs and USP 43 Monographs

Natto is a traditional Japanese fermented soybean dish that is known for its unique texture and flavor. It is also a rich source of natto powder k2, specifically the menaquinone-7 (MK7) form of vitamin K2( natto powder k2).

Menaquinone-7 or MK-7 is a type of Vitamin K2 that is found in "natto," a traditional soy-based dish in Asia. MK-7 is highly bioavailable and is absorbed better than Vitamin K1 found in other food products. Its primary function is to aid in the carboxylation and binding of calcium to specific bone proteins. Furthermore, studies have demonstrated that Vitamin K2 MK-7 plays a role in regulating calcium in the arteries, which supports both circulatory and skeletal health simultaneously.

Calcific atherosclerosis is a crucial factor in the development of cardiovascular disease, which is a leading cause of morbidity and mortality in developed countries. To prevent acute and chronic complications and improve patient survival, it is essential to quantify the risk and understand the mechanisms responsible for arterial calcification. Vitamin K2 has been demonstrated to inhibit the formation of vascular calcification mainly by carboxylating proteins that regulate calcium deposition in atherosclerotic plaques. Currently, the most reliable method for evaluating VK2 metabolism and deficiency is by assessing VK2 activity. Although data on VK2 supplementation are available for special populations, such as dialysis patients, there are no globally accepted guidelines for its everyday medical use.

In all patients diagnosed with calcific atherosclerosis, it is mandatory to assess the overall cardiovascular risk, and an accurate evaluation of VK2 dietary intake is critical to investigate their carential status. Patients with intestinal dysmicrobism require particular attention, although the effect of gut microbiota intervention on VK2 metabolism is still under debate and necessitates specific studies, including microbial metagenomic characterization and functional correlations.

Vitamin K has emerged as a promising vitamin in the prevention of cardiovascular accidents and complications. Adequate dietary supplementation and possible correction of bacterial dysbiosis could be crucial for its physiological effects on vascular calcification. At our center, a multidisciplinary study group is investigating VK2 status in selected patients. This study involves determining MGP carboxylation levels in blood samples and conducting a food frequency questionnaire to establish a correlation between VK2 deficiency and intimal-medial thickness and stiffness of carotid arteries, the presence of calcific atherosclerosis, and signs of intestinal microbiota alterations.

(From Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis, European Review for Medical and Pharmacological Sciences)

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